Réaction #67576

Équation de réaction

3-hydroxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester

phosgene

→

3-Chlorocarbonyloxy-3-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Solvants

THF

toluene

Conditions de réaction

Traitement

1. 1
   Autresolvents were removed under reduced pressure and co-evaporate with CH2Cl2

Mode opératoire

A solution of 3-hydroxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester (200 mg, 1.00 mmol) in THF (4 mL) was slowly treated with phosgene 20% in toluene (0.954 mL). After stirring at rt for 16 h, solvents were removed under reduced pressure and co-evaporate with CH2Cl2. The crude 3-chlorocarbonyloxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester was used directly in the next step.

Source