Réaction #67502

Équation de réaction

2-cyano-3-fluoro-benzenesulfonyl chloride

thiazolidine

→

2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

Solvants

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   ConcentrationThe reaction mixture is concentrated in vacuo
2. 2
   AutrePurification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1)
3. 3
   Lavageby acidic washing with a 1M HCl solution

Mode opératoire

440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.

Source