Réaction #67228

ord-0b11b57e306f4930a0001484a8ee8958

Équation de réaction

Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
CCNC
N-methylethanamine
→
CCN(C)C[C@H]1COc2c(Cl)cc(S(C)(=O)=O)cc2O1
N-{[(2S)-5-CHLORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}-N-METHYLETHANAMINE

Réactifs

Cc1ccc(S(=O)(=O)OC[C@H]2COc3c(Cl)cc(S(C)(=O)=O)cc3O2)cc1
[(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
—
( 5 )
—
( 3 )
—
( 3 )
—
( 2 )
CCNC
N-methylethanamine

Réactifs

Aucun

Solvants

CC#N
ACN

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutrePreparation

Mode opératoire

Preparation according to Example 57 using [(2R)-5-chloro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.027 g, 0.062 mmol), N-methylethanamine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 319 (M+, 0.3), 85 (3), 84 (3), 73 (5), 72 (bp), 63 (2).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08524766B2uspto-grants-2013_09