Réaction #67214

ord-50f1173cba8f414795f0f73418295756

Équation de réaction

Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate
CCNC
N-methylethanamine
→
CCN(C)CC1COc2c(F)cc(S(C)(=O)=O)cc2O1
N-{[5-FLUORO-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}-N-METHYLETHANAMINE

Réactifs

—
( 4 )
Cc1ccc(S(=O)(=O)OCC2COc3c(F)cc(S(C)(=O)=O)cc3O2)cc1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate
CCNC
N-methylethanamine
—
( 2 )
—
( 2 )

Réactifs

Aucun

Solvants

CC#N
ACN

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutrePreparation

Mode opératoire

Preparation according to Example 42 using [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl-4-methylbenzenesulfonate (0.005 g, 0.012 mmol), N-methylethanamine (0.5 ml), ACN (1 ml). MS m/z (rel. intensity, 70 eV) 303 (M+, 0.5), 84 (2), 73 (4), 72 (bp), 69 (2).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08524766B2uspto-grants-2013_09