Réaction #67200

ord-776d8d166897428782ab5a791ad0b3e1

Équation de réaction

Cc1ccc(S(=O)(=O)OCC2COc3ccc(S(C)(=O)=O)cc3O2)cc1
[7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
CC(C)CN
2-methylpropan-1-amine
→
CC(C)CNCC1COc2ccc(S(C)(=O)=O)cc2O1
2-METHYL-N-{[7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}PROPAN-1-AMINE

Réactifs

—
( 6 )
Cc1ccc(S(=O)(=O)OCC2COc3ccc(S(C)(=O)=O)cc3O2)cc1
[7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
CC(C)CN
2-methylpropan-1-amine
—
( 8 )
—
( 20 )

Réactifs

Aucun

Solvants

CC#N
ACN

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutrePreparation

Mode opératoire

Preparation according to Example 25 using [7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.018 g, 0.046 mmol), 2-methylpropan-1-amine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 299 (M+, 6), 256 (20), 86 (bp), 70 (6), 57 (8).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08524766B2uspto-grants-2013_09