Réaction #66945

Équation de réaction

hydrochloric acid

sodium hydroxide

3-ethoxy-4-hydroxybenzaldehyde

acetone

→

yellow crystal

Rendement 70.4%

4-(3-Ethoxy-4-hydroxyphenyl)-3-buten-2-one

Rendement 70.4%

Solvants

ethanol

water

Conditions de réaction

Traitement

1. 1
   Filtrationthe precipitated yellow solid was collected by filtration
2. 2
   Lavagewashed with water and ethanol successively
3. 3
   Autredried
4. 4
   Autrerecrystallized from 95% ethanol

Mode opératoire

10% sodium hydroxide aqueous solution (80 ml) was added under stirring to a solution of 3-ethoxy-4-hydroxybenzaldehyde (16.6 g, 100 mmol) in acetone (50 ml), 95% ethanol (50 ml) and water (400 ml). The reaction mixture was stirred for 24 hr at room temperature, after the reaction completed, the reaction mixture was neutralized with 6N hydrochloric acid to adjust pH=7.0, the precipitated yellow solid was collected by filtration, washed with water and ethanol successively, dried, and then recrystallized from 95% ethanol to give 14.5 g of a yellow crystal, mp: 98-100° C., yield 70.4%.

Source