Réaction #66836

Équation de réaction

tert-butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate

tert-Butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate

5-amino-4-fluoro-2-methylphenol

→

title compound

4-Fluoro-2-methyl-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

Conditions de réaction

Traitement

1. 1
   Autreto yield 2.69 g (100%)

Mode opératoire

The title compound was prepared in analogy to Example 65A from tert-butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate from Example 11A (2.20 g, 6.75 mmol) and 5-amino-4-fluoro-2-methylphenol (1.00 g, 7.09 mmol) to yield 2.69 g (100%).

Source