Réaction #66825

Équation de réaction

Water

2-(chloromethyl)pyridine hydrochloride

potassium carbonate

5-Nitroindazole

→

title compound

Rendement 50.5%

5-Nitro-1-(pyridin-2-ylmethyl)-1H-indazole

Rendement 50.5%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was heated for 4 h to 75° C
2. 2
   Extractionthe mixture was extracted with ethyl acetate
3. 3
   SéchageThe organic layer was dried over sodium sulfate
4. 4
   Autrethe solvent was removed in vacuo
5. 5
   AutreThe crude product was purified by column chromatography on silica gel (eluent: gradient cyclohexane/ethyl acetate 1:1 to ethyl acetate)

Mode opératoire

5-Nitroindazole (10.0 g, 61.3 mmol) was dissolved in THF (100 mL), and 2-(chloromethyl)pyridine hydrochloride (8.60 g, 52.4 mmol) and potassium carbonate (24.4 g, 184 mmol) were added. The mixture was heated for 4 h to 75° C. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, and the solvent was removed in vacuo. The crude product was purified by column chromatography on silica gel (eluent: gradient cyclohexane/ethyl acetate 1:1 to ethyl acetate) to yield 6.73 g (43%) of the title compound.

Source