Réaction #66751

Équation de réaction

5-bromo-2-hydroxyacetophenone

N-Boc-piperidin-4-one

pyrrolidine

MeOH

→

tert-Butyl 6-bromo-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

Solvants

H2O

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureunder reflux until the reaction
3. 3
   TempératureThe mixture was cooled
4. 4
   Filtrationthe mixture was filtered
5. 5
   Autredried
6. 6
   Autreto give

Mode opératoire

A mixture of 5-bromo-2-hydroxyacetophenone (104 g, 485 mmol), N-Boc-piperidin-4-one (98.6 g, 494 mmol), 20 mL of pyrrolidine (17.3 g, 243 mmol) and 261 mL of MeOH was heated under reflux until the reaction was complete. The mixture was cooled, then 87 mL of H2O were added, and the mixture was filtered and dried to give intended compound as a colorless solid.

Source