Réaction #6673

Équation de réaction

phenothiazine

iodoethane

potassium hydroxide

→

10-Ethylphenothiazine

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 24 hours
2. 2
   TempératureAfter cooling
3. 3
   Filtrationthe reaction mixture was filtered
4. 4
   Autrethe solvent was evaporated
5. 5
   AutreThe product was crystallized from methanol

Mode opératoire

A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.

Source