Réaction #66729

Équation de réaction

4-Oxo-adamantane-1-carboxylic acid methyl ester

→

( 11 )

Rendement 91.5%

4-Oxo-adamantane-1-carboxylic acid

Rendement 91.5%

Solvants

LiOH MeOH

MeOH LiOH

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGstirring
2. 2
   Extractionextracted three times with ethyl acetate
3. 3
   SéchageThe organic layer was dried over sodium sulphate
4. 4
   Autreevaporated to dryness

Mode opératoire

1.64 g of 4-Oxo-adamantane-1-carboxylic acid methyl ester (10) were dissolved in 4 mL of 2M aq. LiOH/MeOH (1:1) and stirred overnight at room temperature. Additional 5 ml of the MeOH/LiOH mixture were added and stirring was continued until conversion was complete. The reaction mixture was acidified and extracted three times with ethyl acetate. The organic layer was dried over sodium sulphate and evaporated to dryness to give 1.4 g of (11) as a solid. Rt=0.87 min (Method 3). Detected mass: 195.2 (M+H+).

Source