Réaction #66718

Équation de réaction

N-(4-Isopropyl-3-methoxy-phenyl)-acetamide

HCl

→

HCl

Rendement 60.0%

4-Isopropyl-3-methoxy-phenylamine

Conditions de réaction

Traitement

1. 1
   Autreformed
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Lavagethe crystals were washed 1 N HCl
4. 4
   Autredried under vacuum

Mode opératoire

N-(4-Isopropyl-3-methoxy-phenyl)-acetamide (14.5 g, 69.9 mmol) in 200 ml 6 N HCl was heated to 95° C. for 3.0 hours. The reaction mixture was cooled to room temperature, and allowed to sit for 72 hours at room temperature, during which time crystals formed. The reaction mixture was filtered, and the crystals were washed 1 N HCl and dried under vacuum to give 4-Isopropyl-3-methoxy-phenylamine as an HCl salt (7.6 g, 60%).

Source