Réaction #6596

Équation de réaction

ethyl 2-(cyclohexyloxyacetyl)-4-pentenoate

sodium hydroxide

→

1-cyclohexyloxy-hex-5-en-2-one

Rendement 58.6%

Solvants

ether

Conditions de réaction

Traitement

1. 1
   AutreThe organic phase is separated off
2. 2
   Concentrationconcentrated
3. 3
   workup.DISTILLATIONthe residue is distilled

Mode opératoire

140 g of ethyl 2-(cyclohexyloxyacetyl)-4-pentenoate are heated under reflux in 650 g of 5% strength aqueous sodium hydroxide solution for 4 hours. 500 ml of ether are added to the reaction mixture. The organic phase is separated off and concentrated and the residue is distilled. About 60 g of 1-cyclohexyloxy-hex-5-en-2-one are obtained. (Temperature (bottom)=115°-155° C., temperature (top)=83° C.; 0.8 mbar).

Source