Réaction #659355

Équation de réaction

1-(2-Chloropyridin-3-yl)propan-1-one

[4-(benzyloxy)phenyl]hydrazine hydrochloride

→

title compound

Rendement 25.7%

1-[4-(Benzyloxy)phenyl]-3-ethyl-1H-pyrazolo[3,4-b]pyridine

Rendement 25.7%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated
2. 2
   AutreThe residue was purified by basic silica gel column chromatography (hexane/ethyl acetate)

Mode opératoire

1-(2-Chloropyridin-3-yl)propan-1-one (600 mg) and [4-(benzyloxy)phenyl]hydrazine hydrochloride (976 mg) were dissolved in ethanol (10 ml), and the mixture was stirred under microwave irradiation at 170° C. for 3 hr, and concentrated. The residue was purified by basic silica gel column chromatography (hexane/ethyl acetate) to give the title compound (300 mg). MS (API+): [M+H]+ 330.1.

Source