Réaction #65837

ord-a465c113fb3143f7b0110f62b2c0a2d9

Équation de réaction

COC1(c2ccc(Sc3ccc(C(C)=O)cc3)s2)CCN(CC(F)(F)F)C1
3-[2-(4-acetylphenylthio)thien-5-yl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine
Cl.NO
hydroxylamine hydrochloride
→
COC1(c2ccc(Sc3ccc(C(C)=NO)cc3)s2)CCN(CC(F)(F)F)C1
3-{2-[4-(1-hydroxyiminoethyl)phenylthio]thien-5-yl}-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine
Rendement 63.0%

Réactifs

COC1(c2ccc(Sc3ccc(C(C)=O)cc3)s2)CCN(CC(F)(F)F)C1
3-[2-(4-acetylphenylthio)thien-5-yl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine
Cl.NO
hydroxylamine hydrochloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Using an analogous procedure to that described in Example 27, 3-[2-(4-acetylphenylthio)thien-5-yl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine was reacted with hydroxylamine hydrochloride to give 3-{2-[4-(1-hydroxyiminoethyl)phenylthio]thien-5-yl}-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine as a gum in 63% yield.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05420298uspto-grants-1995_05