Réaction #65737

Équation de réaction

acetic anhydride

sodium formate

Phenylglycine ethyl ester hydrochloride

acetic anhydride

→

N-Formylphenylglycine ethyl ester

Solvants

formic acid

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe mixture was stirred at 50°-60° C. for 1.5 hours
2. 2
   workup.DISTILLATIONAfter the solvent was distilled off
3. 3
   Extractionextracted with ethyl acetate
4. 4
   LavageThe organic layer was washed with a saturated aqueous solution of sodium chloride
5. 5
   Séchagedried over magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off
7. 7
   Autreto afford an oily product

Mode opératoire

Phenylglycine ethyl ester hydrochloride (21.5 g; 0.1 mol) was dissolved in 200 ml of formic acid, whereto sodium formate (8.16 g; 1.2 eq.) was added, followed by adding dropwise acetic anhydride (20 ml; 2.1 eq.). After two hours' stirring, 10 ml of acetic anhydride was added dropwise, and the mixture was stirred at 50°-60° C. for 1.5 hours. After the solvent was distilled off, the residue was neutralized with an aqueous solution of sodium hydrogencarbonate and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride and dried over magnesium sulfate. The solvent was distilled off to afford an oily product.

Source