Réaction #657271

Équation de réaction

(2,6-Dimethyl-piperidin-1-yl)-acetic acid hydrochloride

(2,6-Dimethyl-piperidine-1-yl)-acetic acid hydrochloride

N-hydroxysuccinimide

→

(2,6-Dimethyl-piperidine-1-yl)-acetic acid-(2,5-dioxo-pyrrolidine-1-yl)-ester

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   FiltrationThe residue was filtered
2. 2
   Autrethe filtrate was evaporated in vacuo to dryness
3. 3
   workup.DISSOLUTIONAfter dissolving the residue in 300 ml CH2Cl2
4. 4
   Lavagethe solution was washed with NaHCO3
5. 5
   Séchagedried over sodium sulphate
6. 6
   Autrethe solvent was evaporated
7. 7
   AutreThe compound was then recrystallised from diisopropylether (activated charcoal)

Mode opératoire

12.60 g (60 mMol) (2,6-Dimethyl-piperidin-1-yl)-acetic acid hydrochloride (5), in 100 ml DMF, was added to 7.02 g (60 mMol) N-hydroxysuccinimide and 12.58 g (60 mMol) N,N-dicyclohexylcarbodiimide. The reaction mixture was stirred for 16 h at RT. The residue was filtered and the filtrate was evaporated in vacuo to dryness. After dissolving the residue in 300 ml CH2Cl2, the solution was washed with NaHCO3, dried over sodium sulphate and the solvent was evaporated. The compound was then recrystallised from diisopropylether (activated charcoal).

Source