Réaction #657261

Équation de réaction

trimethyl 1-trityl-3,4,5-pyrazoletricarboxylate

LiAlH4

→

1-trityl-3,4,5-tris(hydroxymethyl)pyrazole

Rendement 73.0%

Solvants

THF

Et2O

Conditions de réaction

Traitement

1. 1
   AutreAfter this time, the reaction was quenched by the slow addition of 1.5 mL of distilled water
2. 2
   workup.ADDITIONfollowed by addition of 1.5 mL of 10% NaOH and 3.5 mL of water
3. 3
   AutreThe solids formed
4. 4
   Autrewere removed by filtration, and 80 mL of dichloromethane
5. 5
   workup.ADDITIONwas added to the filtrate
6. 6
   AutreThe organic phase was separated
7. 7
   Lavagewashed with distilled water (70 mL)
8. 8
   Autreafter separation from the aqueous phase
9. 9
   Séchagewas dried over MgSO4
10. 10
    AutreAfter separation of the organic phase
11. 11
    Autrethe solvent was evaporated under vacuum
12. 12
    Autreyielding a yellowish solid

Mode opératoire

To a solution of trimethyl 1-trityl-3,4,5-pyrazoletricarboxylate (3.034 g, 6.26 mmol) in dry THF (60 mL) were added 50 mL of 1.0 M LiAlH4 in Et2O. The resulting solution was stirred for about 16 h at room temperature (20-25° C.). After this time, the reaction was quenched by the slow addition of 1.5 mL of distilled water, followed by addition of 1.5 mL of 10% NaOH and 3.5 mL of water. The solids formed were removed by filtration, and 80 mL of dichloromethane was added to the filtrate. The organic phase was separated, washed with distilled water (70 mL) and, after separation from the aqueous phase, was dried over MgSO4. After separation of the organic phase, the solvent was evaporated under vacuum yielding a yellowish solid. Yield: 73% (1.823 g, 4.54 mmol).

Source