Réaction #657260

Équation de réaction

trimethyl-3,4,5-pyrazoletricarboxylate

pyrazole

sodium hydride

trityl chloride

→

title compound

Rendement 90.0%

Trimethyl 1-trityl-3,4,5-pyrazoletricarboxylate

Rendement 90.0%

Solvants

dimethylformamide

Conditions de réaction

Traitement

1. 1
   AutreThe synthesis of this compound
2. 2
   AutreAfter removal of the solvent under vacuum
3. 3
   Lavagethe resulting residue was washed with distilled water, n-hexane
4. 4
   Autrefinally dried under vacuum

Mode opératoire

The synthesis of this compound was done by tritylation of trimethyl-3,4,5-pyrazoletricarboxylate (1680 mg, 6.94 mmol) using a procedure similar to the one described in examples 2 and 3 for the synthesis of other tritylated pyrazole derivatives. The starting pyrazole reacted with sodium hydride (405 mg, 10.13 mmol) in dry dimethylformamide (80 mL) for 30 min at room temperature. Then, trityl chloride (1935 mg, 6.94 mmol) was added and the reaction mixture stirred overnight at room temperature. After removal of the solvent under vacuum, the resulting residue was washed with distilled water, n-hexane, and finally dried under vacuum to afford the title compound, as a white microcrystalline solid. Yield: 90% (3.034 g, 6.26 mmol).

Source