Réaction #65428

Équation de réaction

3-methyl-4-phenylthiobenzoic acid

sulfuric acid

methanol

→

methyl 3-methyl-4-phenylthiobenzoate

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 4 hours
2. 2
   AutreAfter reaction
3. 3
   Concentrationthe reaction mixture was concentrated in vacuo, and 1.5 liters of ethyl acetate
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   Lavagethe mixture was washed with saturated brine (400 ml×3)
6. 6
   Séchagedried with anhydrous sodium sulfate
7. 7
   Concentrationconcentrated in vacuo

Mode opératoire

A mixture was 85 g of 3-methyl-4-phenylthiobenzoic acid, 20 ml of concentrated sulfuric acid, and 1.2 liters of methanol was refluxed for 4 hours while stirring. After reaction, the reaction mixture was concentrated in vacuo, and 1.5 liters of ethyl acetate was added to the residue, and the mixture was washed with saturated brine (400 ml×3), and dried with anhydrous sodium sulfate, concentrated in vacuo, and methyl 3-methyl-4-phenylthiobenzoate was obtained (80.33 g).

Source