Réaction #65232

Équation de réaction

3-[4-(4-phenylpiperazino)butyl]indole-5-carboxylic acid

N-methylmorpholine

tert-butylamine

1-hydroxybenzotriazole

3-dimethylaminopropyl-N'-ethylcarbodiimide hydrochloride

→

3-[4-(4-phenylpiperazino)butyl]indole-5-carboxylic acid N-tert-butylamide

Solvants

DMF

DMF

DMF

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGThe mixture is stirred for 16 hours at 20°
2. 2
   Autrethe filtrate is evaporated

Mode opératoire

A solution of 3.74 g of 3-[4-(4-phenylpiperazino)butyl]indole-5-carboxylic acid in 500 ml of DMF is treated with 1.01 g of N-methylmorpholine. A solution of one equivalent of tert-butylamine in 5 ml of DMF, 1.35 g of 1-hydroxybenzotriazole and a solution of 1.92 g of N-(3-dimethylaminopropyl-N'-ethylcarbodiimide hydrochloride in 20 ml of DMF are added with stirring. The mixture is stirred for 16 hours at 20° and the filtrate is evaporated. After working up in a conventional manner, 3-[4-(4-phenylpiperazino)butyl]indole-5-carboxylic acid N-tert-butylamide is obtained.

Source