Réaction #649743

Équation de réaction

Imatinib

methanesulfonic acid

→

imatinib mesylate

Solvants

1,3-dioxolane

Conditions de réaction

Mode opératoire

Imatinib base (1 g) was suspended in 1,3-dioxolane (4.5 ml) at 15° C. Aqueous methanesulfonic acid (0.125 ml in 0.5 ml of water) was added obtaining the solution of imatinib mesylate. The solution thus formed was cool down to about 10° C. and additional portion of 1,3-dioxolane (15 ml) was added into the mixture. The suspension was stirred at 5° C. for 3 h, providing form VI. The white solid was filtered, washed with 1,3-dioxolane, and the solid matter was dried first for 6 h at RT and than for 6 h at 60° C. under flow of nitrogen to obtain imatinib mesylate Form V (1.0 g, yield: 84%).

Source