Réaction #64249

Équation de réaction

trans-4-nitroxycyclohexylamine

4-butyrolactone

→

4-Hydroxy-N-(trans-4-nitroxycyclohexyl)-butyric acid amide

Conditions de réaction

Traitement

1. 1
   AutreFor the removal of the excess lactone, it
2. 2
   Filtrationis filtered over a silicic gel acid with ethyl acetate
3. 3
   AutreAfter collection of the pure fractions, it
4. 4
   workup.DISTILLATIONis distilled in a vacuum
5. 5
   Autretriturated with ether
6. 6
   Filtrationfiltered off with suction

Mode opératoire

4.8 g (0.03 mol) trans-4-nitroxycyclohexylamine are mixed with 5.7 ml 4-butyrolactone and stirred for 3 d at room temperature. For the removal of the excess lactone, it is filtered over a silicic gel acid with ethyl acetate. After collection of the pure fractions, it is distilled in a vacuum, triturated with ether and filtered off with suction. There remain 2.1 g of the title compound of the melting point 58°-60° C., i.e. 28% of theory.

Source