Réaction #640541

Équation de réaction

6-aminonicotinic acid

ethanol

→

white solid

Ethyl 6-Aminonicotinate

Conditions de réaction

Traitement

1. 1
   Autrewas bubbled in dry hydrochloric acid at 0° C.
2. 2
   Températurethe solution was refluxed until all the solids
3. 3
   workup.DISSOLUTIONdissolved
4. 4
   AutreThe solvents were removed under reduced pressure
5. 5
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
6. 6
   Lavagewashed with saturated sodium bicarbonate, brine
7. 7
   Concentrationconcentrated

Mode opératoire

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

Source