Réaction #640533

Équation de réaction

4-[1-(3-methoxy-4-hydroxyphenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

DIPEA

methoxymethyl chloride

→

title compound

4-[1-(3-Methoxy-4-methoxymethoxy-phenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

Solvants

DMF

ethyl acetate

Conditions de réaction

Traitement

1. 1
   Lavagewashed with water
2. 2
   Séchagedried over sodium sulphate
3. 3
   FiltrationFiltration of the sodium sulphate and concentration of the filtrate under reduced pressure

Mode opératoire

A mixture of 4-[1-(3-methoxy-4-hydroxyphenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.10 g, 0.27 mmol), DIPEA and methoxymethyl chloride in dry DMF is stirred at room temperature for 14 hours. The reaction mixture is diluted with ethyl acetate, washed with water and dried over sodium sulphate. Filtration of the sodium sulphate and concentration of the filtrate under reduced pressure gives the title compound as colorless, pure solid, m.p. 190° C.

Source