Réaction #640522

Équation de réaction

4-(1H-benzimidazol-2-yl)-furazan-3-ylamine

potassium carbonate

iodomethoxy benzene

→

title compound

4-(1-Phenoxymethyl-1H-benzimidazol-2-yl)-furazan-3-ylamine

Conditions de réaction

Traitement

1. 1
   AutreEvaporation of the solvent under reduced pressure
2. 2
   Autrepartitioning of the resulting residue between water and ethyl acetate
3. 3
   Séchageby drying of the organic solution over sodium sulphate and chromatography of the residue

Mode opératoire

To a solution of 4-(1H-benzimidazol-2-yl)-furazan-3-ylamine (0.10 g, 0.497 mmol) is added potassium carbonate (0.172 g, 1.24 mmol) and iodomethoxy benzene (0.128 g, 0.546 mmol). The mixture is stirred over night. Evaporation of the solvent under reduced pressure and partitioning of the resulting residue between water and ethyl acetate followed by drying of the organic solution over sodium sulphate and chromatography of the residue gives the title compound as a colorless solid, m.p. 171-173° C.

Source