Réaction #640517

Équation de réaction

4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine

sodium bicarbonate

hydroxylamine hydrochloride

→

title compound

4-[1-(4-Bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine oxime

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températureis refluxed for 20 hours
2. 2
   AutrePartitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase
3. 3
   Autreby drying
4. 4
   Autreevaporation of the solvent
5. 5
   Autregives the crude product
6. 6
   AutrePurification by chromatography on silicagel

Mode opératoire

A mixture of 4-[1-(4-bromophenacyl)-1H-benzimidazol-2-yl]-furazan-3-ylamine (0.083 g, 0.21 mmol, prepared according to Example 1), sodium bicarbonate (0.021 g, 0.25 mmol) and hydroxylamine hydrochloride (0.014 g, 0.21 mmol) in ethanol (5 ml) is refluxed for 20 hours. Partitioning of the reaction mixture between ethyl acetate and water, separation of the organic phase followed by drying and evaporation of the solvent gives the crude product. Purification by chromatography on silicagel yields the title compound as an E/Z-mixture, m.p. 198-201° C.

Source