Réaction #63936

Équation de réaction

2',4'-Dichloro-2-(1H-1,2,4-triazol-1-yl)prop-2-enophenone

trimethylsulphoxonium iodide

cetrimide

sodium hydroxide

→

1-(1H-1,2,4-Triazol-1-yl)cyclopropyl 2,4-dichlorophenyl ketone

Solvants

1,1,1-trichloroethane

1,1,1-trichloroethane

Conditions de réaction

Traitement

1. 1
   TempératureAfter refluxing for a further 15 minutes the organic phase
2. 2
   Températureafter cooling
3. 3
   Autrewas separated
4. 4
   AutreEvaporation
5. 5
   Autregave a gum

Mode opératoire

2',4'-Dichloro-2-(1H-1,2,4-triazol-1-yl)prop-2-enophenone (0.27 g, 1.0 mMole) was added dropwise in 1,1,1-trichloroethane (2 ml) to a refluxing mixture of trimethylsulphoxonium iodide (0.33 g, 1.5 mMole), cetrimide (0.03 g), 1,1,1-trichloroethane (5 ml) and aqueous 2N sodium hydroxide (3 ml) with vigorous stirring over 2 minutes. After refluxing for a further 15 minutes the organic phase, after cooling was separated. Evaporation gave a gum, weight 0.11 g.

Source