Réaction #63935

Équation de réaction

2',4'-dichloro-2-(1H-1,2,4-triazol-1-yl)acetophenone

methyl iodide

sodium hydride

→

title compound

2', 4'-Dichloro-2-(1H-1,2,4-triazol-1-yl)propiophenone hydrochloride

Solvants

tetrahydrofuran

Conditions de réaction

Mode opératoire

Alkylation of 2',4'-dichloro-2-(1H-1,2,4-triazol-1-yl)acetophenone (8.64 g) with methyl iodide (5.27 g) in the presence of sodium hydride (as a 50% dispersion in oil, total weight of dispersion 1.78 g) in tetrahydrofuran (150 ml) at 0° over 2 hours, yielded the title compound which was isolated as a hydrochloride salt, m.p. 125°-129°, 3.17 g (yield 34.8%).

Source