Réaction #63933

Équation de réaction

N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide

thiosemicarbazide

→

yellow crystals

Rendement 44.8%

N-Ethyl-N-[3-(3-amino-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]propanamide

Rendement 44.8%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONThe mixture was treated
2. 2
   Autrethe product chromatographed
3. 3
   AutreRecrystalization of the product from dichloromethane-hexane

Mode opératoire

A solution of 5.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.2 g thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was treated and the product chromatographed as described for Example 70. Recrystalization of the product from dichloromethane-hexane afforded 2.4 g yellow crystals, mp 199°-200° C.

Source