Réaction #63871

Équation de réaction

N-(3-Hydroxybenzyl)piperidine

6-bromohexanenitrile

potassium carbonate

→

6-(3-piperidinomethylphenoxy)hexanenitrile

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture was cooled
2. 2
   Filtrationfiltered
3. 3
   AutreThe solvent was removed by evaporation
4. 4
   Températurethe residue was heated
5. 5
   Autreto remove unreacted 6-bromohexanenitrile

Mode opératoire

N-(3-Hydroxybenzyl)piperidine (9.55 g) was heated with 6-bromohexanenitrile (10.2 g) and potassium carbonate (13.8 g) under reflux in acetone (150 ml) for 66 hours. The reaction mixture was cooled and filtered. The solvent was removed by evaporation and the residue was heated with stirring at 100° C. for one hour to remove unreacted 6-bromohexanenitrile and to yield 6-(3-piperidinomethylphenoxy)hexanenitrile as an oil.

Source