Réaction #63634

Équation de réaction

N-(2-mercaptopropanoyl)thiazolidine-4-carboxylic acid

→

6-methyl-1H,3H-thiazolo[4,3-c][1,4]thiazine-5,8-dione

Rendement 50.8%

Solvants

water

Conditions de réaction

Traitement

1. 1
   Extractionextracted with ethyl acetate
2. 2
   LavageThe organic layer was washed with water and brine
3. 3
   Séchagedried over magnesium sulfate
4. 4
   Filtrationfiltered
5. 5
   Concentrationconcentrated

Mode opératoire

Polyphosphoric acid (36 g) was added to N-(2-mercaptopropanoyl)thiazolidine-4-carboxylic acid (1.5 g, 6.78 mmol) and the mixture stirred at 50° for a period of 4 hours. The reaction mixture was then dissolved in water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate, filtered and concentrated to give 0.7 g of 6-methyl-1H,3H-thiazolo[4,3-c][1,4]thiazine-5,8-dione as a pale yellow oil.

Source