Réaction #63522

Équation de réaction

N-(4-Aminophenethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline dihydrochloride

HBr

→

N-(4-aminophenethyl)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline dihydrobromide

Conditions de réaction

Traitement

1. 1
   Températuremaintained under nitrogen
2. 2
   Températureheated to 120° for 18 hr
3. 3
   Autreafter which time a white solid had precipitated
4. 4
   TempératureThe mixture was cooled
5. 5
   Filtration, and the solid collected by filtration
6. 6
   LavageThe solid was washed three times with isopropanol and vacuum
7. 7
   Autredried at 100° for 48 hr

Mode opératoire

N-(4-Aminophenethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline dihydrochloride (10.0 g, 0.025 m) was dissolved in 49% HBr (25 ml) maintained under nitrogen and heated to 120° for 18 hr. after which time a white solid had precipitated. The mixture was cooled and the solid slurried with isopropanol (50 ml), stirred for 1 hr., and the solid collected by filtration. The solid was washed three times with isopropanol and vacuum dried at 100° for 48 hr. to give 8.5 g N-(4-aminophenethyl)-1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline dihydrobromide as an off-white solid, m.p. 275°-278°.

Source