Réaction #63461

Équation de réaction

6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one

triethylamine

3,4-dimethoxybenzoylchloride

→

6-(3,4-Dihydro-4-(3,4-dimethoxyphenylcarbonyl)-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   Températurethe mixture heated
2. 2
   Températureat reflux for four hours
3. 3
   LavageThe solution was washed with sodium bicarbonate solution
4. 4
   Autreevaporated to dryness
5. 5
   AutreThe residue was chromatographed on silica gel eluting with 1:1 ethyl acetate
6. 6
   AutreThe title compound was collected as white needles, mp 207°-208° C.

Mode opératoire

6-(3,4-Dihydro-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one was dissolved in methylene chloride and 1.1 equivalent of triethylamine. 1.1 equivalent of 3,4-dimethoxybenzoylchloride was added and the mixture heated at reflux for four hours. The solution was washed with sodium bicarbonate solution and then evaporated to dryness. The residue was chromatographed on silica gel eluting with 1:1 ethyl acetate:ethyl ether. The title compound was collected as white needles, mp 207°-208° C.

Source