Réaction #63248

Équation de réaction

5-(2-propyl-3,4dichlorophenoxy)pentyl bromide

sodium cyanide

→

5-(2-propyl-3,4-dichlorophenoxy)pentane nitrile

Solvants

dimethylformamide

Conditions de réaction

Traitement

1. 1
   AutreThe solution was evaporated in vacuo and ethyl acetate and water
2. 2
   workup.ADDITIONwere added to the residue
3. 3
   AutreThe layers were separated
4. 4
   Lavagethe organic layer was washed several times with a saturated sodium chloride solution
5. 5
   FiltrationThe organic solution was filtered through sodium sulfate
6. 6
   Autreevaporated to dryness
7. 7
   Autreto give 1.38 g

Mode opératoire

A solution of 1.6 g. of 5-(2-propyl-3,4dichlorophenoxy)pentyl bromide and 0.22 g. of sodium cyanide were heated overnight at 75°-85° C. in 50 ml. of dimethylformamide. The solution was evaporated in vacuo and ethyl acetate and water were added to the residue. The layers were separated and the organic layer was washed several times with a saturated sodium chloride solution. The organic solution was filtered through sodium sulfate and evaporated to dryness to give 1.38 g. of the desired sub-title intermediate. NMR.

Source