Réaction #632027

Équation de réaction

3-quinuclidinone

benzaldehyde

sodium hydroxide

→

(Z)-2-benzylidenequinuclidin-3-one

Rendement 91.2%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 1.5 h
2. 2
   TempératureAfter the solution was cooled
3. 3
   Autrethe yellow precipitates
4. 4
   Autrewere collected
5. 5
   Lavagewashed with ethanol
6. 6
   Autredried

Mode opératoire

A mixture of 3-quinuclidinone (20.9 g, 167 mmol), benzaldehyde (17.7 g, 167 mmol), and one pellet of sodium hydroxide in 75 mL of ethanol was refluxed for 1.5 h. After the solution was cooled, the yellow precipitates were collected, washed with ethanol, and dried to give (Z)-2-benzylidenequinuclidin-3-one (32.5 g, yield: 91.2%, mp 130-132° C.).

Source