Réaction #632021

Équation de réaction

4-(5-nitro-pyrimidin-2-yl)-1,4-diaza-bicyclo[3.2.2]nonane

→

2-(1,4-Diaza-bicyclo[3.2.2]non-4-yl)-pyrimidin-5-ylamine

Rendement 100.0%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction-mixture was filtered through celite
2. 2
   Lavagewas washed with ethanol (50 ml)
3. 3
   AutreThe product was dried
4. 4
   Autreevaporated

Mode opératoire

A mixture of 4-(5-nitro-pyrimidin-2-yl)-1,4-diaza-bicyclo[3.2.2]nonane (0.71 g, 2.85 mmol), palladium (0.25 g, 10% on activated carbon) and methanol (50 ml) was stirred under hydrogen for 10 min. The reaction-mixture was filtered through celite and was washed with ethanol (50 ml). The product was dried and evaporated. Yield 100%.

Source