Réaction #632010

Équation de réaction

N-tert-butyl-(1-methyl)cyclopropylsulfonamide

methyl benzoate

→

N-tert-butyl-(1-benzoyl)cyclopropyl-sulfonamide

Rendement 66.0%

Conditions de réaction

Traitement

1. 1
   AutreThis compound was obtained in 66% yield
2. 2
   AutreThe crude product was purified by column chromatography over SiO2 using 30% to 100% dichloromethane in hexane

Mode opératoire

This compound was obtained in 66% yield using the procedure described for the synthesis of N-tert-butyl-(1-methyl)cyclopropylsulfonamide using 1.2 equivalents of methyl benzoate as the electrophile. The crude product was purified by column chromatography over SiO2 using 30% to 100% dichloromethane in hexane: 1H NMR (CDCl3) δ 1.31 (s, 9H), 1.52 (m, 2H), 1.81 (m, 2H), 4.16 (br s, 1H), 7.46 (m, 2H), 7.57 (m, 1H), 8.05 (d, J=8.5 Hz, 2H).

Source