Réaction #631971

ord-43b48e2ce5cd45609b530a2602e1348d

Équation de réaction

C=CC(=O)OCCC(=O)O
2-Carboxyethyl acrylate
O=S(Cl)Cl
Thionyl chloride
→
C=CC(=O)OCCC(=O)Cl
desired product
C=CC(=O)OCCC(=O)Cl
3-chloro-3-oxopropyl acrylate

Réactifs

C=CC(=O)OCCC(=O)O
2-Carboxyethyl acrylate
O=S(Cl)Cl
Thionyl chloride

Réactifs

Aucun

Solvants

ClCCl
CH2Cl2

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Températurethe solution is cooled in an ice bath
  2. 2
    AutreThe solvent is removed under reduced pressure

Mode opératoire

2-Carboxyethyl acrylate (1 eq.) is dissolved in CH2Cl2 and the solution is cooled in an ice bath. Thionyl chloride (1 eq.) is added dropwise and the mixture is allowed to warm to room temperature and stir for 4 hours. The solvent is removed under reduced pressure and the desired product is isolated by vacuum distillation.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07935131B2uspto-grants-2011_05