Réaction #63186

Équation de réaction

2-(4-oxo-3-thiazolidinyl)propionic acid

2.6-dimethylaniline

dicyclohexylcarbodiimide

→

N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide

Rendement 45.7%

Solvants

chloroform

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 48 hours
2. 2
   AutreThe resultant precipitate was removed by filtration
3. 3
   Autrethe filtrate was evaporated in vacuo
4. 4
   AutreThe residue was triturated with diethyl ether
5. 5
   Autrerecrystallized from ethanol

Mode opératoire

A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.

Source