Réaction #63181

Équation de réaction

6-(2-bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone

6-(2-bromopropionyl)-3,4,dihydro-3-methyl-2(1H)-quinazolinone

potassium acetate

acetic acid

→

6-(2-acetoxypropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone

Solvants

water

Conditions de réaction

Traitement

1. 1
   Températureis refluxed for three hours
2. 2
   Extractionextracted with methylene chloride (3×50 ml)
3. 3
   Lavagethe combined organic layers are washed with saturated aqueous sodium bicarbonate
4. 4
   Autredried
5. 5
   Filtrationfiltered
6. 6
   Concentrationconcentrated

Mode opératoire

A mixture of 6-(2-bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone (2 g) prepared in Step 1, potassium acetate (2.64 g) and glacial acetic acid (20 ml) is refluxed for three hours. The reaction mixture is diluted with water and extracted with methylene chloride (3×50 ml) and the combined organic layers are washed with saturated aqueous sodium bicarbonate, dried, filtered and concentrated to obtain 6-(2-acetoxypropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone which is used in the next step.

Source