Réaction #631329

Équation de réaction

4-(4-chlorophenyl)-3-buten-2-one

diethyl oxalate

sodium ethoxide

→

Ethyl 6-(4-chlorophenyl)-2,4-dioxo-hex-5-enoate

Solvants

diethyl ether

diethyl ether

Conditions de réaction

Traitement

1. 1
   Températurecooled to 5°-10° C. by an ice bath
2. 2
   Autreto precipitate after 5 minutes

Mode opératoire

A solution of 4-(4-chlorophenyl)-3-buten-2-one (27.1 g) and diethyl oxalate (21.9 g) in dry diethyl ether (200 ml) was added dropwise over 15 minutes to a stirred suspension of sodium ethoxide (3.45 g of sodium dissolved in absolute ethanol and excess ethanol evaporated off) in dry diethyl ether (400 ml) cooled to 5°-10° C. by an ice bath. A yellow solid began to precipitate after 5 minutes.

Source