Réaction #62993

Équation de réaction

pyrrolidine

2-chloroethoxyethoxyethanol

KOH

→

N-(hydroxyethoxyethoxyethyl)pyrrolidine

Rendement 76.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurerefluxed for an additional hour
2. 2
   FiltrationFiltration and distillation

Mode opératoire

A total of 295 g of pyrrolidine and 250 g of 2-chloroethoxyethoxyethanol in 750 ml of ethanol was refluxed for 5 hours. The reaction mixture was then treated with 106 g of KOH and refluxed for an additional hour. Filtration and distillation yielded 229 g of N-(hydroxyethoxyethoxyethyl)pyrrolidine (b.p.=145° C. at 3 mm).

Source