Réaction #6296

Équation de réaction

4-fluorobenzaldehyde

N-butyl-N-4-hydroxybutylamine

potassium carbonate

→

4-(N-4-hydroxybutyl-N-butylamino)benzaldehyde

Solvants

dimethylsulfoxide

Conditions de réaction

Traitement

1. 1
   AutreTo a three neck flask fitted with a mechanical stirrer
2. 2
   TempératureAfter cooling to room temperature
3. 3
   Filtrationthe solid product is collected by filtration
4. 4
   Autrepurified by recrystallization from tetrahydrofuran/benzene

Mode opératoire

To a three neck flask fitted with a mechanical stirrer, a thermometer, and a condenser, is added 124 g (1 mole) of 4-fluorobenzaldehyde, 145.3 g (1 mole) of N-butyl-N-4-hydroxybutylamine, 138.2 g (1 mole) of anhydrous potassium carbonate, and dimethylsulfoxide. The mixture is then heated at 95° C. until the reaction is complete. After cooling to room temperature, the solution is poured into a four-fold excess of ice water, and the solid product is collected by filtration and purified by recrystallization from tetrahydrofuran/benzene.

Source