Réaction #62919

ord-ee20f050eb1d4574be5d0bef495c23e6

Équation de réaction

O=Cc1ccccc1
benzaldehyde
O=Cc1ccc(F)cc1
p-fluorobenzaldehyde
NC1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2)C1
acid ( 1 )
NC1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2)C1
1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid
Cc1ccc(C=NC2CCN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3)C2)cc1
cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(p-fluorobenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid
Cc1ccc(C=NC2CCN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3)C2)cc1
1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(4-methylbenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

In the described fashion of Example 1 replacing benzaldehyde and p-fluorobenzaldehyde and using the acid (1) (R=cyclopropyl) described in Example 19 one obtains 1 cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-(p-fluorobenzylidene)amino-1-pyrrolidinyl)-quinoline-3-carboxylic acid (3) (R=cyclopropyl, Z=p-fluorophenyl). mp 228°-229° C.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04762845uspto-grants-1988_08