Réaction #62785

Équation de réaction

Trichloroacetyl chloride

N-(3-chloro)allyl-N-methoxyethylamine

triethylamine

→

above-named product

Rendement 92.7%

N-(3-chloro)allyl-N-methoxyethyl trichloroacetamide

Rendement 92.7%

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   AutreThe reaction was kept at approximately 5° C. with an ice-water bath
2. 2
   workup.ADDITIONUpon completion of the addition
3. 3
   LavageThe reaction mixture was then washed twice with saturated brine
4. 4
   Séchagedried with sodium sulfate
5. 5
   AutreRotary evaporation

Mode opératoire

N-(3-chloro)allyl-N-methoxyethylamine (2.25 g, 0.015 mol) and 1.52 g (0.015 mol) triethylamine were stirred in 70 ml dichloromethane. The reaction was kept at approximately 5° C. with an ice-water bath. Trichloroacetyl chloride (2.73 g, 0.015 mol) in 10 ml dichloromethane was added dropwise to the cooled solution. Upon completion of the addition, the mixture was stirred at room temperature for 6 hours. The reaction mixture was then washed twice with saturated brine and dried with sodium sulfate. Rotary evaporation yielded 4.1 g of the above-named product.

Source