Réaction #62734

Équation de réaction

7-Ethoxy-8-nitroquinoline

→

8-Amino-7-ethoxyquinoline

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Concentrationthe filtrate concentrated to 10 mL
3. 3
   AutreThe title compound crystallized as yellow needles (1.86 g, 82%)

Mode opératoire

7-Ethoxy-8-nitroquinoline (2.62 g, 12.0 mmole), in absolute ethanol (200 mL) was shaken with 10% palladium on carbon (0.10 g) under hydrogen (50 psi) for 3 hr. The catalyst was filtered off and the filtrate concentrated to 10 mL. The title compound crystallized as yellow needles (1.86 g, 82%); mp 94°-95°. Anal. Calcd for C11H12N2O: C, 70.19; H, 6.43; N, 14.88. Found: C, 70.16; H, 6.47; N, 14.87.

Source