Réaction #62166

Équation de réaction

water

2-Chloromethyl-quinoline

4-Hydroxy-benzamide

cesium carbonate

→

title compound

Rendement 45.0%

4-(Quinolin-2-ylmethoxy)-benzamide

Rendement 45.0%

Solvants

dimethyl formamide

Conditions de réaction

Traitement

1. 1
   Extractionextracted with chloroform, dried magnesium sulfate
2. 2
   Filtrationfiltered
3. 3
   Concentrationconcentrated

Mode opératoire

To a solution of 2-Chloromethyl-quinoline (1.57 g) and 4-Hydroxy-benzamide (995 mg) in dimethyl formamide (20 mL) was added cesium carbonate (7.3 g) and the reaction mixture heated at 80° C. for 18 h. The reaction mixture was poured into water and extracted with chloroform, dried magnesium sulfate, filtered and concentrated to provided the title compound (909 mg). MS: (M+H -m/z=279.3).

Source