Réaction #62152

Équation de réaction

sodium bicarbonate

acetic acid

(4-Benzyloxy-phenyl)-hydrazine hydrogen chloride

→

title compound

2-(4-Benzyloxy-phenyl-2H-pyrazol-3-yl]-pyridine

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Extractionextracted with ethyl acetate, dried magnesium sulfate
2. 2
   Filtrationfiltered
3. 3
   Concentrationconcentrated
4. 4
   AutrePurification via combiflash MPLC

Mode opératoire

To a solution of 3-Dimethylamino-1-pyridin-4-yl-propenone (590 mg) in methanol (10 ml) was added acetic acid (0.5 ml) and (4-Benzyloxy-phenyl)-hydrazine hydrogen chloride (836 mg) and the reaction mixture heated to 60° C. for 6 h. The reaction mixture was poured into saturated sodium bicarbonate, extracted with ethyl acetate, dried magnesium sulfate, filtered and concentrated. Purification via combiflash MPLC provided the title compound (795 mg). MS: (M+H m/z=328.1).

Source