Réaction #62044

Équation de réaction

HCl

4-Isothiocyanato-benzoic acid t-butyl ester

4-isothiocyanato-benzoic acid t-butyl ester

KOH

cyanoacetamide

→

4-(2-Carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester

Rendement 83.5%

4-(2-carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester

Rendement 83.5%

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   Autrethe precipitate obtained
2. 2
   Filtrationwas filtered
3. 3
   Lavagewashed with water
4. 4
   Autredried under vacuum

Mode opératoire

4-Isothiocyanato-benzoic acid t-butyl ester 2 (28.3 gm, 120.4 mmol) was taken into DMF (200 ml). To this KOH (6.74 gm, 120.4 mmol) and cyanoacetamide (10.21 gm, 120.4 mmol) were added. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was acidified with 1N HCl, the precipitate obtained was filtered, washed with water, and dried under vacuum, to provide 32.10 gm of 4-(2-Carbamoyl-2-cyano-thioacetylamino)-benzoic acid t-butyl ester 3.

Source